GENE366 MOLECULAR BIOLOGY OF THE GENE
| Course Code: | 2190366 |
| METU Credit (Theoretical-Laboratory hours/week): | 3 (3.00 - 0.00) |
| ECTS Credit: | 5.0 |
| Department: | Molecular Biology and Genetics |
| Language of Instruction: | English |
| Level of Study: | Undergraduate |
| Course Coordinator: | Prof.Dr. AYŞE ELİF ERSON BENSAN |
| Offered Semester: | Spring Semesters. |
Course Objectives
To develop an an understanding of molecular mecahnisms of gene expression regulation in eukaryotes. the topics we will cover are:
Chapter 4 Content of Genome Chapter 5 Genome sequences and evolution
Chapter 9,10,11. DNA replication (+ read chapter 10 (Klug) for prokaryotes)
Chapter 13-16. Homologous and site-specific recombination, Somatic DNA recombination
Chapter 14. DNA repair
Chapter 15. Transposable elements and retroviruses
Chapter 18. Eukaryotic transcription (+ read Chapter 17 for prokaryotes)
Chapter 19. Splicing and processing
Chapter 20. mRNA stability and localization
Chapter 21/29. Catalytic RNA and Non-coding RNA
Chapter 22/23. Translation (eukaryotic) Chapter 26 Eukaryotic gene regulation (+ read Chapter 24 for prokaryotes)
Course Content
The course presents prokaryotic and eukaryotic molecular genetics with a comparative and unifying approach. DNA structure and organization, replication, transcription, translation, regulation of gene expression and interactions of proteins and RNAs with DNA are discussed. Examples from bacteria, yeasts, plant and humans are covered. Advances at the molecular level in the areas of aging, gene therapy, and mitochondrial inheritance will be emphasized. Recent advances in recombinant DNA technology (such as PCR restriction fragment length polymorphism, chromosome walking and jumping) also are included. The course has been designed for the students of Molecular Biology & Genetics Program.
Course Learning Outcomes
Students will have a comprehensive view of how the information flow from DNA to proteins is managed in cells. The students must recall previously-learned concepts of genetics and build new information on these basic concepts.
Program Outcomes Matrix
| Level of Contribution | |||||
| # | Program Outcomes | 0 | 1 | 2 | 3 |
| 1 | Apply the most advanced and current experimental techniques in genetic engineering, molecular biology and molecular genetics | ✔ | |||
| 2 | Practice and defend the work safety rules | ✔ | |||
| 3 | Have a commend of scientific processes; critique; design experiments and ask questions leading to theorizing | ✔ | |||
| 4 | Communicate in English and Turkish with high proficiency | ✔ | |||
| 5 | Read and interpret the current worldwide literature in molecular biology and genetics | ✔ | |||
| 6 | Pursue the most recent advances in molecular biology and genetics; explain and relate the advances to colleagues | ✔ | |||
| 7 | Challenge technical and technological riddle and welcome life-long education | ✔ | |||
| 8 | Work individually or as a team member, easily start and propagate brain storm in a work group | ✔ | |||
| 9 | Employ and defend scientific ethic rules and make them motto for their team | ✔ | |||
0: No Contribution 1: Little Contribution 2: Partial Contribution 3: Full Contribution