BIOL405 IMMUNE SYSTEM RELATED DISEASES
| Course Code: | 2380405 |
| METU Credit (Theoretical-Laboratory hours/week): | 3 (3.00 - 0.00) |
| ECTS Credit: | 6.0 |
| Department: | Biology |
| Language of Instruction: | English |
| Level of Study: | Undergraduate |
| Course Coordinator: | Assist.Prof.Dr BANU BAYYURT KOCABAŞ |
| Offered Semester: | Spring Semesters. |
Course Objectives
1. Explain how the mucosal immune system operates (principles of mucosal immunology; microbiota and the immune system; tolerance induction; helminthic infections)
2. Describe failures of Host Defense Mechanisms (evasion and subversion by pathogens; primary and secondary immunodeficiencies)
3. Explain Allergy and Allergic Diseases (Hypersensitivity reactions, regulatory mechanisms, mast cells, basophils, eosinophils)
4. Describe Autoimmunity (Mechanisms of central & peripheral tolerance development, organ-specific & systemic autoimmune diseases)
5. Explain principles of Transplantation immunology (including fetal tolerance and immune-suppressive treatments)
6. Explain Tumor Immunology (immune evasion, development of suppressor cells, immunotherapeutic approaches to treat cancers)
7. Explain inflammation relation with neurodegenerative diseases and aging
Course Content
Introduction to failures of host defense mechanisms, allergy and allergic diseases, autoimmunity, and manipulation of the immune response
Prerequisites: BIO 407
Course Learning Outcomes
1. communicate major scientific principles linking innate and adaptive immunity
2. describe common operational principles pertaining to self versus non-self discrimination
3. describe how self-tolerance develops and break-down of tolerogenic mechanisms
4. analyze the mucosal immune system and identify how microbiota affects development of the immune system and modify responses
5. describe primary and secondary immune deficiencies
6. understand allergy and 4 different types of hypersensitivity reactions
7. understand the development of various autoimmune diseases and mechanisms that underly the pathology
8. describe transplant rejection (acute and chronic) and fetal tolerance; identify major tolerogenic mechanisms at the maternal fetal interface
9. apply critical thinking and creativity in the field of immunotheraputics for the development of vaccines, or treatment of immunodeficiencies, allergies, autoimmune diseases, organ transplant rejection, neurodegenerative diseases and/or cancers.
Program Outcomes Matrix
| Level of Contribution | |||||
| # | Program Outcomes | 0 | 1 | 2 | 3 |
| 1 | Perform basic laboratory and field techniques/approaches used in various branches of biology. | ✔ | |||
| 2 | Understand and apply principles of laboratory and field safety. | ✔ | |||
| 3 | Understand the inner workings of the scientific processes, think critically, and frame questions using experimental and theoretical approaches in biology. | ✔ | |||
| 4 | Proficiency in communicating issues in both English and Turkish. | ✔ | |||
| 5 | Read, and understand scientific communications from primary literature in biology. | ✔ | |||
| 6 | Identify and explain issues in biological sciences. | ✔ | |||
| 7 | Be ready to take new theoretical and technological challenges by recognizing the value and act upon the need for lifelong learning. | ✔ | |||
| 8 | Work as an individual, as well as a team member, and assume leadship when needed. | ✔ | |||
| 9 | Follow the rules of scientific ethics within their careers and professions. | ✔ | |||
0: No Contribution 1: Little Contribution 2: Partial Contribution 3: Full Contribution