GENE455 EPIGENETICS IN HEALTH AND DISEASE
| Course Code: | 2190455 |
| METU Credit (Theoretical-Laboratory hours/week): | 3 (3.00 - 0.00) |
| ECTS Credit: | 5.0 |
| Department: | Molecular Biology and Genetics |
| Language of Instruction: | English |
| Level of Study: | Undergraduate |
| Course Coordinator: | Assist.Prof.Dr NİHAL TERZİ ÇİZMECİOĞLU |
| Offered Semester: | Fall Semesters. |
Course Objectives
Course Content
Accurate and timely gene expression is crucial for all aspects of life and therefore, is regulated on several layers during transcription and translation. In eukaryotes, one layer of control is observed on the chromatin level which signifies the packaging of genomic DNA around nucleosomes. Nucleosomes can be post-translationally modified to allow or prevent access of RNA Polymerase II to underlying DNA sequences. Epigenetics is modulation of gene expression without any modification of the underlying DNA sequence. In this course, students will learn how proper gene expression is achieved on chromatin level and then apply their knowledge to examples of advanced epigenetic control. In this course, students will learn how proper gene expression is achieved on chromatin level and then apply their knowledge to examples of advenced epigenetic control.In this course, students will learn how proper gene expression is achieved on chromatin level and apply their knowledge to biological processes with advanced epigenetic control (stem cell biology, development, cancer, neural disorders and immunity). Special emphasis will be given to experimental approaches in epigenetic research.
Course Learning Outcomes
Program Outcomes Matrix
| Level of Contribution | |||||
| # | Program Outcomes | 0 | 1 | 2 | 3 |
| 1 | Apply the most advanced and current experimental techniques in genetic engineering, molecular biology and molecular genetics | ✔ | |||
| 2 | Practice and defend the work safety rules | ✔ | |||
| 3 | Have a commend of scientific processes; critique; design experiments and ask questions leading to theorizing | ✔ | |||
| 4 | Communicate in English and Turkish with high proficiency | ✔ | |||
| 5 | Read and interpret the current worldwide literature in molecular biology and genetics | ✔ | |||
| 6 | Pursue the most recent advances in molecular biology and genetics; explain and relate the advances to colleagues | ✔ | |||
| 7 | Challenge technical and technological riddle and welcome life-long education | ✔ | |||
| 8 | Work individually or as a team member, easily start and propagate brain storm in a work group | ✔ | |||
| 9 | Employ and defend scientific ethic rules and make them motto for their team | ✔ | |||
0: No Contribution 1: Little Contribution 2: Partial Contribution 3: Full Contribution