GENE433 MOLECULAR MODELING AND PROTEIN STRUCTURE PREDICTION
| Course Code: | 2190433 |
| METU Credit (Theoretical-Laboratory hours/week): | 3 (2.00 - 2.00) |
| ECTS Credit: | 9.0 |
| Department: | Molecular Biology and Genetics |
| Language of Instruction: | English |
| Level of Study: | Undergraduate |
| Course Coordinator: | Prof.Dr. ÇAĞDAŞ DEVRİM SON |
| Offered Semester: | Fall Semesters. |
Course Objectives
By the end of this course, the students will:
- Identify and explain the basic principles of 3D modeling and protein structure prediction
- Distinguish between the available softwares to model a protein sequence.
- Describe structure function relation for biological macromolecules
Course Content
Current developments in biology, nanotechnology, biotechnology and large scale DNA sequencing increased the role of protein structure prediction more important than ever. The objective of this course is to provide a background for the molecular biologist by outlining the principle concepts and limitations in 3D protein modeling. The available algorithms, programs and data banks used in modeling and protein structure prediction will be reviewed. More importantly methods to evaluate the performance of these algorithms and programs will be discussed as a new approach in modeling and structure prediction emerges almost every day.
Course Learning Outcomes
- Outline the factors effecting protein structure and function
- Evaluate many software applications used in the protein modeling and docking
- Define problems in various modeling approaches
- Determine which modeling method best fits to a given problem
- List and distinguish the possible approaches for Ab initio Protein Modeling
- Apply homology modeling
- Evaluate the necessity of sequence alignment in modeling
- Outline and explain docking and evaluate the possible applications of molecular dynamic and montecarlo simulations.
Program Outcomes Matrix
| Level of Contribution | |||||
| # | Program Outcomes | 0 | 1 | 2 | 3 |
| 1 | Apply the most advanced and current experimental techniques in genetic engineering, molecular biology and molecular genetics | ✔ | |||
| 2 | Practice and defend the work safety rules | ✔ | |||
| 3 | Have a commend of scientific processes; critique; design experiments and ask questions leading to theorizing | ✔ | |||
| 4 | Communicate in English and Turkish with high proficiency | ✔ | |||
| 5 | Read and interpret the current worldwide literature in molecular biology and genetics | ✔ | |||
| 6 | Pursue the most recent advances in molecular biology and genetics; explain and relate the advances to colleagues | ✔ | |||
| 7 | Challenge technical and technological riddle and welcome life-long education | ✔ | |||
| 8 | Work individually or as a team member, easily start and propagate brain storm in a work group | ✔ | |||
| 9 | Employ and defend scientific ethic rules and make them motto for their team | ✔ | |||
0: No Contribution 1: Little Contribution 2: Partial Contribution 3: Full Contribution