BIOL752 DIVERSIFYING PROTEIN FUNCTIONS: CONCEPTS AND APPROACHES
| Course Code: | 2380752 |
| METU Credit (Theoretical-Laboratory hours/week): | 3 (3.00 - 0.00) |
| ECTS Credit: | 8.0 |
| Department: | Biology |
| Language of Instruction: | English |
| Level of Study: | Graduate |
| Course Coordinator: | |
| Offered Semester: | Fall and Spring Semesters. |
Course Objectives
1. explain what is meant by post-translational processing (PTPs) of proteins
2. describe the main types of PTP and how different PTPs alter the function of proteins
3. explain how de-regulation of PTP could lead to malignancies
4. compare/contrast approaches and techniques used in PTP studies and design experimental approaches aimed at solving a particular question in PTP
Course Content
-Increasing the functional diversity of proteins through post-translational modifications (PTM).
-Protein splicing,glycosylation,phosphorylation,methylation,acetylation,ubiquitination as examples of PTMs
-Mechanisms of alterations in structure,stability,function,localization and degradation of proteins within the cell
-Integrated effects of PTMs on protein functions
-Deregulation of PTMS and emergences of pathologies
Course Learning Outcomes
1. describe the basic principles of post-translational processing
2. compare/contrast molecular components and regulatory events of a particular PTP
3. analyze how PTPs are tightly and coordinantly regulated
4. explain how PTPs affect protein structure and function
5. describe how cell uses various PTPs amplify, change and block extracellular signaling
6. execute methods and approaches commonly used to analyze PTPs
7. describe, evaluate and communicate scientific literature in signal transduction